Major Injuries Reported in Two-Vehicle Crash on I-280 in Daly City
Daly City, CA – December 2, 2025 – At least one person suffered major injuries early Monday following a two-vehicle collision on Interstate 280 in Daly City, according to the California Highway Patrol. The crash occurred around 2:19 a.m. on the southbound side of I-280, just north of the John Daly Boulevard off-ramp. The vehicles involved were a Nissan Pathfinder and a Honda CR-V. Fire crews responded and provided aid to at least one individual with serious injuries. CHP has not yet determined what led to the crash as the investigation remains ongoing.
